Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform

Year: 2025

Type: article

Abstract: activity to established PPM1D inhibitors. Our approach yielded multiple allosteric inhibitors of PPM1D, deepened our understanding of PPM1D as a drug target, and is highly amenable to studying other modulators of the DDR and p53.

Source: iScience

DOI: 10.1016/j.isci.2025.112069

Institutions: Broad Institute, Harvard University, Massachusetts General Hospital, Brigham and Women's Hospital, Dana-Farber Cancer Institute

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: U.S. Department of Defense, Edward P. Evans Foundation, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1846689970, G5720317402, G602600179, G8611108388, G8975711554, The role of SRCAP in therapy related clonal hematopoiesis

OpenAlex ID: W4407793958