Contributions from light level and spectral content on refractive development in young rabbits
Year: 2025
Type: article
Abstract: AIM: To compare the effects of manipulating light levels versus manipulating the spectral content of short wavelengths (blue light) of ambient lighting on refractive development in young rabbits. METHODS: A total of 32 healthy 3-week-old rabbits were randomly assigned to one of the four groups with 8 in each group for 12wk: Control group (NC) under low blue light (output ratio of blue light 1.8%) at low illuminance (341 lx), HI group under low blue light (output ratio of blue light 1.6%) at high illuminance (5057 lx), simulating natural light (S-NL) group under high blue light (output ratio of blue light 4.9%) at high illuminance (5052 lx), and MB group under high blue light (output ratio of blue light 5.2%) at low illuminance (342 lx). The lighting in each group were provided by light emitting diode (LED) lamps emitting visible light (range 380-780 nm) in addition to (or not) LED lamps only emitting short wavelength (range 380-500 nm). Refraction, axial length, and corneal curvature radius were assessed by retinoscopy, ultrasonography and keratometry, respectively. Average data of both eyes for each animal were used as single values and compared among groups. RESULTS: >0.05). CONCLUSION: The light levels per se but not the rich in spectral content of short wavelengths determine the inhibitory effect of ambient lighting on myopia development in rabbits.
Authors: Xiu-Ping Tang, Hao-Bo Fan, Yun-Chun Zou
Institutions: North Sichuan Medical University, Nanchong Central Hospital
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,800
OpenAlex ID: W4407796272