Prevalence and Factors Associated With Proton Pump Inhibitors (PPIs) Use: A Cross‐Sectional Study of PERSIAN Guilan Cohort Study
Year: 2025
Type: article
Abstract: ABSTRACT Background and Aims Proton pump inhibitors (PPIs) are used extensively in the treatment of patients with upper gastrointestinal disorders. In this study, we aimed to investigate the prevalence of PPI consumption and related factors in the Prospective Epidemiological Research Studies in Iran (PERSIAN) Guilan Cohort study (PGCS) population. Methods This was a cross‐sectional study form the PGCS, and investigated 10,520 participants for PPI consumption, which were divided into two groups: users and nonusers. Demographical data, clinical characteristics, and PPI types were recorded. The data were analyzed using SPSS version 16 and GraphPad Prism version 9, and a significance level of 0.05 was considered. Results The prevalence of PPI use in the overall participants was 4.8%, and it was higher in females compared to males (6.1% vs. 3.3%). According to the regression analysis, being in the overweight category was associated with a 26% lower likelihood of PPI use (p = 0.021). Low physical activity was linked to a 1.72‐fold higher odds of PPI consumption (p < 0.001). Individuals with reflux, multiple underlying diseases, and the use of nonsteroidal anti‐inflammatory drugs (NSAIDs) had significantly higher odds ratios for PPI consumption (p < 0.001). Conclusion This study highlights the concerning trend of increasing PPI use and identifies low physical activity, reflux, multiple underlying diseases, and NSAID use associated with higher risk of PPI use. It emphasizes the need for caution in prescribing PPIs and raising awareness among both healthcare providers and patients about the potential risks and side effects.
Source: Health Science Reports
DOI: 10.1002/hsr2.70494
Institution: Guilan University of Medical Sciences
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,280
OpenAlex ID: W4407796772