Work

Untangling Traffic Jams: RAB11FIP4 Orchestrates Cellular Recovery in Cystinosis

Year: 2025

Type: editorial

Abstract: RAB11FIP4 (RAB11 family interacting protein 4), a RAB11A (Ras-related protein Rab-11) effector protein downregulated in cystinosis, plays a crucial role in cellular trafficking. Reconstitution of RAB11FIP4 in cystinotic cells restores multiple cellular functions, including lysosomal trafficking, autophagy, and the endoplasmic reticulum stress response. These findings identify RAB11FIP4 as both a key player in cystinosis pathogenesis and a promising therapeutic target. The purpose of this punctum is to highlight how restoring RAB11FIP4 expression rescues cellular homeostasis in cystinosis through the regulation of trafficking pathways.

Source: Autophagy Reports

DOI: 10.1080/27694127.2025.2466121

Authors: Mouad Ait Kbaich, Jennifer L. Johnson, Sergio D. Catz

Institution: Scripps Research Institute

Language: English

Topic: Biomedical Research and Pathophysiology

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Heart, Lung, and Blood Institute