Work

Localization and expression dynamics of an RNA Pol I core subunit in response to fasting in C. elegans

Year: 2024

Type: article

Abstract: , fasting reduces pre-rRNA levels. However, whether this reduction stems from a regulation of RNA Pol I expression remains unclear. Here, we examined how the nutritional status affects the localization and expression levels of RPOA-2 , a core subunit of RNA Pol I, in the intestine. We found that RPOA-2 retains its nucleolar localization regardless of animals being fed, fasted or fed after fasting. Interestingly, fasting reduces RPOA-2 protein amounts which are restored upon feeding. These findings suggest that the availability of RNA Pol I core subunits contributes to the regulation of rDNA transcription in response to nutrients.

Source: PubMed

DOI: 10.17912/micropub.biology.001472

Authors: Nada Al-Refaie, Francesco Padovani, Kurt M. Schmoller, Daphne S. Cabianca

Institutions: Helmholtz Munich, Institute of Functional Epigenetics, Ludwig-Maximilians-Universität München

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Zero hunger

Open Access status: green

Funder: Deutsche Forschungsgemeinschaft