Work

SCF RMF -dependent degradation of the nuclear lamina releases the somatic chromatin mobility restriction for meiotic recombination

Year: 2025

Type: article

Abstract: Meiosis prepares the genome for sexual reproduction and is a driver of genetic diversity. Essential for both aspects are rapid chromosome movements enabling the pairing of homologous chromosomes, thereby promoting their recombination and ensuring their correct segregation afterward. However, it is unknown how meiocytes reorganize their nuclear architecture when chromosomes are tethered to the nuclear lamina in somatic cells. Here, we reveal the meiosis-specific Skp1–Cul1–F-box-protein (SCF) E3 ubiquitin ligase SCF RMF as a key regulator of this reorganization in Arabidopsis . We find that the nuclear lamina proteins of the CRWN family are degraded in an SCF RMF -dependent manner in this process. Thus, the SCF RMF functions to release the somatic constraints on chromosome mobility through disrupting the nuclear lamina, allowing homologous chromosomes to pair.

Source: Science Advances

DOI: 10.1126/sciadv.adr4567

Authors: Xinjie Yuan, Bowei Cai, Yuki Hamamura, Arp Schnittger, Chao Yang

Institutions: Huazhong Agricultural University, Universität Hamburg, Max Planck Institute of Molecular Plant Physiology

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,500

OpenAlex ID: W4407802882

FWCI: 2.03

Cites: 41

Cited by: 8

Related to: 10