Work

One-Pot NIS-Promoted Cyclization/Palladium-Catalyzed Carbonylation for the Selective Synthesis of HFIP Ester-Containing Indenes and Thiochromenes

Year: 2025

Type: article

Abstract: Practical and atom-economic procedures for the selective synthesis of HFIP ester-containing indenes/thiochromenes from the same propargylic thioethers and HFIP have been developed via one-pot NIS-promoted cyclization/palladium-catalyzed carbonylation. Solvent plays an important role in this transformation, and the reactions proceed selectively and efficiently to afford a variety of HFIP ester-containing indenes and thiochromenes in moderate to excellent yields. In addition, the use of formic acid as the CO source could avoid manipulation of toxic CO gas.

Source: ACS Organic & Inorganic Au

DOI: 10.1021/acsorginorgau.5c00005

Authors: Pengfei Ji, Xing-Feng Pan, Xinxin Qi, Xiao-Feng Wu

Institutions: Zhejiang Sci-Tech University, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Leibniz Institute for Catalysis, Dalian National Laboratory for Clean Energy

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,500

Funder: National Key Research and Development Program of China