Work

Evaluation of the Efficacy of Colchicine, Pirfenidone and Prednisolone in Preventing Stricture Due to Inflammation as a Result of Urethral Mucosal Damage in Rats

Year: 2025

Type: article

Abstract: What's known on the subject? and What does the study add?Urethral stricture is a disease characterized by fibrotic scar formation causing narrowing of the urethra, decreased urethral volume, and failure of normal voiding function, and can frequently recur despite endoscopic or open surgical treatment.We administered pirfenidone, colchicine, and corticosteroids orally to prevent proliferation, excessive fibrosis, and scarring during the healing process of urethral stricture.This is the only study in the literature comparing three oral pharmacological agents with known anti-inflammatory and antifibrotic properties to prevent recurrence of urethral stricture.As a result of clinical studies, we believe that the use of these agents before and after all interventions for urethral stricture should be included in clinical practice.

Source: Journal of Urological Surgery

DOI: 10.4274/jus.galenos.2025.2024-12-6

Authors: Fatih Fırat, Kenan Yalçın, Fikret Erdemir, Fikret Gevrek

Institution: Tokat Gaziosmanpaşa Üniversitesi

Language: English

Topic: Urological Disorders and Treatments

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407808895