Work

Fast Esterification Method Mediated by Coupling Reagent NDTP

Year: 2025

Type: article

Abstract: Herein, we report a rapid and mild esterification method using 5-nitro-4,6-dithiocyanatopyrimidine (NDTP) as a coupling reagent, which is effective in alcoholic and nonalcoholic solvents. The esterification process mediated by NDTP allows for the good yield synthesis of esters within just 1 min. A wide range of alcohols and carboxylic acids were effectively esterified under these optimized conditions. The method's rapid execution, high efficiency, and adaptability across diverse substrates make it advantageous for ester synthesis.

Source: ACS Omega

DOI: 10.1021/acsomega.4c09365

Authors: Yiping Li, Haoyu Kuang, Zhouming Shen, Guangjun Bao, Wangsheng Sun

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Lanzhou University

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funders: Lanzhou University, National Natural Science Foundation of China, Chinese Academy of Medical Sciences, Fundamental Research Funds for the Central Universities