Cardiac Considerations in Treatment of Schizophrenia: A Case Report Highlighting the Use of Long-acting Injection Paliperidone Palmitate Depot in Schizophrenia Patient with Comorbid Wolff-Parkinson-White Syndrome
Year: 2025
Type: article
Study design: Case Report
Abstract: The effect of antipsychotics on electron-conduction abnormalities in already diagnosed Wolff-Parkinson-White (WPW) syndrome is underevaluated which creates a dilemma among practitioners in choosing an effective antipsychotic with minimal side effects.Paliperidone, a second-generation antipsychotic, is Food and Drug Administration (FDA) approved for treating schizophrenia, but the studies have documented mixed results on its effect on QT prolongation.Hence, we are going to present a case of paranoid schizophrenia with comorbid WPW syndrome showing a remarkable response on long-acting paliperidone palmitate depot with no effect on QT prolongation, even after a 2-month follow-up of electrocardiogram (ECG) report.
Authors: Suparna Kumar, Sangha Mitra Godi
Institution: Central Institute of Psychiatry
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407814964