Pattern and impact of antidotal administration in an Egyptian tertiary poison control center: A three-year retrospective study (2021–2023)
Year: 2025
Type: article
Study design: Observational Study
Abstract: Timely antidote administration is a critical step in acute poisoning management. Awareness of poisoning patterns and the essential antidotal requirement could improve patient care with better hospital resource allocation. This study investigates the pattern and impact of antidotal administration on patient outcomes in an Egyptian tertiary poison control center, providing insights to optimize the antidote stocking of essential antidotes. A three-year cross-sectional study was conducted at Tanta University Poison Control Center from January 2021 to December 2023. Demographic data, poisoning characteristics, causative agents, and administered antidotal data were retrieved. The initial Poisoning Severity Score (PSS), total hospitalization period, and patient outcomes were also recorded. The included 447 antidote-treated poisoned patients showed near equal gender distribution and median age of 25 years. Atropine, oximes, N-acetylcysteine (NAC), and naloxone were the top administered antidotes among patients (48.3 %, 25.7 %, 19.9 %, and 11.2 %, respectively). Mortality and complications were recorded in 5.15 % and 20.8 %, respectively. Administration of atropine, oximes, NAC, and L-carnitine significantly improved all outcomes ( p < 0.05). Although HBO therapy significantly improved mortality, it substantially increased intensive care unit admissions ( p < 0.001). Despite folic acid administration significantly improved mortality and complication incidences ( p < 0.05), its therapeutic efficiency is still questionable. Availability constraints of the digibind and botulinum antitoxin could affect patient outcomes. Administration of atropine, oximes, NAC, naloxone, and sodium bicarbonate was significantly linked to prolonged hospitalization ( p < 0.001). Accordingly, the emergency department in each institution should regularly update the antidotal stock based on a review of the list of essential and commonly used antidotes. • Antidote administration has a crucial role in the management of acute poisoning. • Atropine, oximes, N-acetylcysteine, and naloxone were the top administered antidotes. • Atropine, oximes, N-acetylcysteine, and L-carnitine improved all patient outcomes. • The therapeutic efficacy of hyperbaric oxygen and folic acid is still questionable. • Antidote stocking should be regularly updated according to the poisoning patterns.
Source: Toxicology Reports
Institution: Tanta University
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,530
OpenAlex ID: W4407818736