Work

Hepatitis B virus induced cirrhosis and hepatocarcinoma: pathogenesis and therapeutics

Year: 2025

Type: article

Abstract: Hepatitis B virus (HBV) infection is a major risk factor of cirrhosis and hepatocellular carcinoma (HCC) worldwide. Pathogenesis of HBV-induced cirrhosis and HCC involves viral factors and virus-triggered local inflammatory and immune responses, the latter leading to progressive fibrosis, cirrhosis and carcinogenesis. Antiviral therapeutics suppress HBV replication and reduce the risks of cirrhosis and HCC. We discuss the current knowledge on the pathogenesis of HBV-induced cirrhosis and HCC, focusing on mechanisms of current and emerging antiviral therapeutics.

Source: Exploration of Digestive Diseases

DOI: 10.37349/edd.2025.100565

Authors: Juntian Yao, Jinsheng Guo, Youhua Xie

Institutions: Shanghai Medical College of Fudan University, Fudan University, Zhongshan Hospital

Language: English

Topic: Hepatitis B Virus Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407819984