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The utility of animal models to inform the next generation of human space exploration

Year: 2025
Type: review
Abstract: Animals have played a vital role in every stage of space exploration, from early sub-orbital flights to contemporary missions. New physiological and psychological challenges arise with plans to venture deeper into the solar system. Advances in chimeric and knockout animal models, along with genetic modification techniques have enhanced our ability to study the effects of microgravity in greater detail. However, increased investment in the purposeful design of habitats and payloads, as well as in AI-enhanced behavioral monitoring in orbit can better support the ethical and effective use of animals in deep space research.
DOI: 10.1038/s41526-025-00460-5
Authors: Isla Duporge, Talmo Pereira, Santiago Castiello de Obeso, Julius G. Bright Ross, Stephen J. Lee, Allyson G. Hindle
Institutions: National Academy of Sciences, Princeton University, Salk Institute for Biological Studies, Yale University, University of Oxford, DEVCOM Army Research Laboratory, United States Army Research Office, University of Nevada, Las Vegas
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,690
Funders: National Aeronautics and Space Administration, National Academies of Sciences, Engineering, and Medicine, Instituto Tecnológico de Aeronáutica, Centre National d’Etudes Spatiales, Nuclear Safety and Security Commission, Agência Espacial Brasileira, Johnson Space Center, U.S. Army, Army Research Laboratory
OpenAlex ID: W4407820271
FWCI: 1.039
Cites: 127
Cited by: 9
Related to: 10