Work

Renal fibrosis: research progress on mechanisms and therapeutic strategies

Year: 2025

Type: article

Abstract: Renal fibrosis (RF) is a prevalent clinical symptom of numerous chronic kidney illnesses and a significant pathological alteration in end-stage renal disease resulting from various mechanisms, such as abnormally activated signaling pathways, microRNAs, aging, autophagy disorders, and fibrotic ecological niches, all of which contribute to RF development. Inhibiting, blocking, or delaying the aforementioned mechanisms may yield novel approaches for treating RF. This article explores advancements in the comprehension of the mechanisms and therapeutic approaches for RF.

Source: Kidney Research and Clinical Practice

DOI: 10.23876/j.krcp.24.158

Authors: Cheng-Xiao Yin, Jia-Rui Fan, Xiao-Gang Du

Institution: The Affiliated Yongchuan Hospital of Chongqing Medical University

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Natural Science Foundation of China