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Cancer evolution could inform targets for personalized anticancer vaccines

Year: 2025

Type: article

Abstract: Through comprehensive genomic and immune analyses, mechanisms of lung cancer resistance after treatment with EGFR inhibition and vaccine therapy were investigated. This case report, together with data from the longitudinal lung cancer study TRACERx, highlight the importance of understanding when targeted variants are acquired during the cancer’s evolutionary history. Treatment-resistance mechanisms identified through longitudinal analysis of cancer clones.

Source: Nature

DOI: 10.1038/d41586-025-00467-8

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $12,690

OpenAlex ID: W4407832775

FWCI:

Cites: 5

Cited by:

Related to: 10