Comparative Evaluation of Preoperative Paracetamol and a Combination of Paracetamol with Nebulized or Intravenous Dexamethasone for Prevention Of Postoperative Sore Throat
Year: 2024
Type: conference-abstract
Abstract: Dear Editor, We read with interest the article by Rathore SS, Prakash S, Mullick P, and Garg B, entitled Comparative evaluation of preoperative paracetamol and a combination of paracetamol with nebulized or intravenous dexamethasone for prevention of postoperative sore throat, published in the Med J DY Patil Vidyapeeth 2024;17:292–8.[1] We congratulate the authors for a well-designed study. However, we have a few queries. POST is a well-documented complication after tracheal intubation.[2]Pharmacological interventions are aimed at prevention, amelioration of symptoms, and treatment of POST. Medications suggested for this purpose include corticosteroids, non-steroidal anti-inflammatory drugs (NSAID), and N-methyl-Daspartate (NMDA) receptor antagonists.[3] The use of glucocorticoids and NSAIDs is justified in the management of POST, considering the role of inflammation in pathogenesis of POST. An updated meta-analysis on the efficacy of dexamethasone in reducing the incidence of POST showed that dexamethasone 0.2 mg/kg significantly decreased the incidence of POST, whereas dexamethasone at a dose of 0.1 mg/kg was not effective.[4]The dose used in the present study was fixed to 8 mg, which amounts to approximately 0.13 mg/kg. Use of a higher dose might be more effective. Such patients already have an intravenous port for drug administration. Hence, use of dexamethasone i.v. would have been more easy for both the patient and the doctor. In this study, dexamethasone, administered by nebulization was not more effective than that given intravenously. Besides this, nebulization formulation of dexamethasone is not easily available in market and adding nebulization of dexamethasone would increase instrumentation and cost. Thanking you, Dr Dange Data availability statement Not applicable. Author contribution Concept of letter - Dr. Suresh Dange, Preparation of text - Dr. Jinitha Panikar & Dr. Sarjanya Gampa, Editing the text - Dr. Saniya, References & literature search - Dr. Bhagyashree Dange. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407834772