Work

Effect of pre-hospital hypertonic saline on neutrophil to lymphocyte ratio in traumatic brain injury: A retrospective analysis

Year: 2025

Type: article

Abstract: Hypertonic saline (HTS) may have anti-inflammatory properties. We aimed to investigate the effect of pre-hospital HTS on neutrophil to lymphocyte ratio (NLR), a simple marker of systematic inflammation, in patients with severe traumatic brain injury (TBIs). We included 110 adults with blunt TBIs requiring pre-hospital anaesthesia (median age 57.1 years, 67% male). On hospital admission, median NLR was lower in patients who received pre-hospital HTS (7.9 vs 11.9, p = 0.021), and in multivariable analysis, HTS use remained associated with NLR ( p = 0.048). We believe our findings highlight the neuroinflammatory properties of HTS as an area for future research.

Source: Journal of the Intensive Care Society

DOI: 10.1177/17511437251320553

Authors: Adam JR Watson, Ryan Riordan, Julian Hannah, Tim Nicholson Roberts, James Plumb

Institutions: University Hospital Southampton NHS Foundation Trust, University of Southampton, Royal Centre for Defence Medicine, NIHR Southampton Biomedical Research Centre

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4407835118

FWCI:

Cites: 3

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Related to: 10