Work

HMGB1 drives T-cell activation in hypertensive males and females

Year: 2025

Type: article

Abstract: There is growing evidence that T-cells contribute to both the development of hypertension and sex differences in blood pressure control. Our work establishes the damage-associated molecular pattern HMGB1 as an important contributor to T-cell activation in hypertension.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00197.2024

Authors: Elizabeth C. Snyder, Riyaz Mohamed, Jennifer C. Sullivan

Institution: Augusta University

Language: English

Topic: Advanced Glycation End Products research

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Heart, Lung, and Blood Institute, NHLBI Division of Intramural Research