Work

Inhibition of kinin B1 receptor alleviates SARS-CoV-2-induced long-lasting cardiovascular complications

Year: 2025

Type: article

Abstract: We are the first to report that elevated B1R expression may drive the long-lasting cardiovascular effects associated with recovery from COVID-19 infection. We have also collected novel evidence showing that blockade of B1R can reduce the cardiac complications associated with long COVID and may serve as a novel therapeutic target to mitigate SARS-CoV-2-induced long-term cardiac damage in affected individuals.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00861.2024

Authors: Drew Theobald, Lisandra E. de Castro Braz, Shaw M. Akula, Jeffrey B. Eells, Srinivas Sriramula

Institution: East Carolina University

Language: English

Topic: Long-Term Effects of COVID-19

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Nursing Research