Work

Mitochondriale und zytosolische Systeme der Eisen-Schwefel-Proteinbiogenese

Year: 2025

Type: article

Abstract: Iron-sulfur (FeS) clusters require a complex biosynthesis pathway, despite the simplicity of these versatile, inorganic protein cofactors. The process starts in mitochondria by action of the iron-sulfur cluster assembly (ISC) machinery and is the essential and minimal function of these organelles. The ISC system further assists the cytosolic iron-sulfur protein assembly (CIA) system in maturing FeS proteins in both cytosol and nucleus. Here, I briefly summarize our current mechanistic knowledge of this essential process of life.

Source: BIOspektrum

DOI: 10.1007/s12268-025-2371-6

Author: Roland Lill

Institutions: Philipps University of Marburg, Loewe Center for Synthetic Microbiology

Language: English

Topic: Metalloenzymes and iron-sulfur proteins

Subfield: Renewable Energy, Sustainability and the Environment

Field: Energy

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,190

OpenAlex ID: W4407840056