Work

How do genome abnormalities impact mitochondrial homeostasis?

Year: 2025

Type: article

Abstract: The genome of eukaryotes encodes thousands of proteins needed to ensure cell health. Hence, an imbalance in the genome has profound consequences for protein homeostasis (proteostasis). The genome and proteome are interlocked in a mutual relationship, which impacts the functions of cellular organelles like mitochondria. However, the underlying mechanisms remain an enigma. Here, we highlight this relationship and outline some open questions to be addressed.

Source: BIOspektrum

DOI: 10.1007/s12268-025-2372-5

Authors: Olha Kurpa, Prince Saforo Amponsah

Institutions: University of Kaiserslautern, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,190

OpenAlex ID: W4407840112