Year: 2025
Type: article
Abstract: The gut microbiome plays a crucial role in human health, but the molecular mechanisms underlying microbial interactions remain poorly understood. Activity-based protein profiling (ABPP) enables functional annotation of uncharacterized enzymes, particularly proteases, using chemical tools. Applying ABPP, Bacteroides fragilis Protease 1 (Bfp1) was identified as an activator of the human protease-activated receptor 2 (PAR2), modulating intestinal inflammation and barrier integrity.
Source: BIOspektrum
Authors: Nayab Shakil, Markus Lakemeyer
Institution: Friedrich Schiller University Jena
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,190
OpenAlex ID: W4407840171