Work

Signaling to survive: linear ubiquitination in health and disease

Year: 2025

Type: article

Abstract: Post-translational modification with ubiquitin (Ub) controls protein stability, localization and function and occurs as single entity, or as poly-Ub chains, linked via lysine residues or the N-terminal methionine (M1 poly-Ub). Generated by the linear ubiquitin chain assembly complex (LUBAC) and counteracted by the deubiquitinating enzymes OTULIN and CYLD, M1 poly-Ub controls immune signaling, survival and cell death. Here, we discuss old and new functions of M1 poly-Ub in health and disease.

Source: BIOspektrum

DOI: 10.1007/s12268-025-2402-3

Authors: Gulustan Celik, Nadine Weinelt, Sjoerd J. L. van Wijk

Institutions: Goethe University Frankfurt, German Cancer Research Center, University Hospital Frankfurt, Deutsches Konsortium für Translationale Krebsforschung

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,190