Year: 2025
Type: article
Abstract: Intracellular sorting of most soluble lysosomal enzymes occurs by tagging with mannose 6-phosphate (M6P) residues in the Golgi apparatus allowing recognition by M6P-receptors and transport to lysosomes. GlcNAc-1-phosphotransferase (GNPT) catalyzes the first step in M6P-tagging. Although the M6P sorting pathway is well-studied and was thought to be completely understood, several novel regulators of GNPT localization and stabilization in the cis-Golgi apparatus have been recently identified.
Source: BIOspektrum
Authors: Zilei Chen, Anna La Rosa, Sabrina Jabs
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,190
OpenAlex ID: W4407840419