Impacts of vaping and marijuana use on airway health as determined by exhaled breath condensate (EBC)
Year: 2025
Type: article
Study design: Observational Study
Abstract: Across the United States, there is increased use of cannabis products and electronic delivery systems for cannabis products and nicotine, yet little is known about their impacts on lung health. We analyzed exhaled breath condensate of 254 participants who were non-users and users who used cannabis and tobacco products. The 132 participants reported using a product ("users") were distributed into cohorts of tobacco products and cannabis products, with some participants following into multiple cohorts. Targeted analysis of inflammatory oxylipins found up-regulation among persons using tobacco products, while cannabis users had concentrations closer to nonusers, and often down-regulated. Untargeted screening of 403 significant metabolites found tobacco users had similar breath profiles, and that cannabis users had a similar profile that was closer to the profile of nonusers. Metabolites were significantly higher in breath of people using combustion products (tobacco and cannabis) relative to nonusers, and significantly lower in e-device users (nicotine and THC). Our work demonstrates the relative impact of e-delivery systems and cannabis products compared to traditional cigarette smoking on lung metabolic profiles.
Source: Respiratory Research
Authors: Dante E. Rojas, Mitchell M. McCartney, Eva Borras, Tristan L. Hicks, Tiffany T. Lam, Nicholas J. Kenyon, Cristina E. Davis
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,490
Funders: U.S. Department of Energy, U.S. Department of Veterans Affairs, Tobacco-Related Disease Research Program, National Institutes of Health, National Nuclear Security Administration, University of California, Davis, Office of the President, University of California, NIH Office of the Director, National Institute of Environmental Health Sciences, National Center for Advancing Translational Sciences, Sandia National Laboratories
Awards: G11630931, G1174330898, G156123175, G1918759989, Exposure assessment, health monitoring, and cancer control in wildland firefighters, G2214935549, G2784247199, G2826625206, G3300389418, G413247060, G4903105778, G5339743583, G5767419451, G5797217813, G6777974675, G717840919, G855168022, G9000025022, G9000025637, G9000036510, G9000036978, UC Davis Environmental Health Sciences Core Center, Monitoring of disease-induced skin VOC patterns from handheld and wearable chemical sensors
OpenAlex ID: W4407842868