A New Synthesis of Polyhydroxylated Cyclopentane β-Amino Acids from Nitro Sugars
Year: 2025
Type: conference-paper
Abstract: A ne stereocontrolled nitro sugar-mediated synthesis of polyhydroxylated β-amino acids is reported. The key step of this approach is a Michael addition of the lithium salt of tris(phenylthio)methane (a carboxyl synthetic equivalent) to sugar nitro olefins. This is followed by the generation of the amino acid functionality by the transformation of the tris(phenylthio)methyl substituent into the carboxylic acid functionality and the reduction of the nitro group to an amino group.
Authors: Ramón J. Estévez, Begoña Pampín, Marcos González, Juan C. Estévez
Institution: Universidade de Santiago de Compostela
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4407850990