Work

Thermoresponsive Nanocarriers Transduced by Inorganic Nanoparticles: Design Considerations and Applications in Drug Delivery

Year: 2025

Type: article

Abstract: Thermoresponsive polymers, which undergo phase transitions within physiologically tolerated temperatures, are key to developing drug delivery systems (DDS) with precise spatial and temporal control, potentially addressing challenges associated with the treatment of complex diseases. Inorganic nanoparticles with unique optical, electronic, and magnetic properties serve as efficient transducers, converting external stimuli into localized heat to trigger thermoresponsive nanocarriers. This review explores the design and application of thermoresponsive nanocarriers transduced by inorganic nanoparticles as DDS. Following a brief description of temperature‐triggered phase transition of polymers and heat generation mechanisms by inorganic nanoparticles, strategies to integrate these components into hybrid systems are described. Examples demonstrating the utility of these hybrid systems as advanced DDS are discussed, highlighting their potential for precise drug release alongside theranostic capabilities by combining therapy with imaging. Despite the challenges in design, synthesis, and biological applications, thermoresponsive polymer‐inorganic hybrids hold immense promise for transforming drug delivery and biomedical innovations.

Source: Helvetica Chimica Acta

DOI: 10.1002/hlca.202400193

Authors: Anamarija Nikoletić, Mirela Maleković, Gül Kozalak, Cornelia G. Palivan, Oya Tagit

Institutions: University of Basel, FHNW University of Applied Sciences and Arts Northwestern Switzerland, Swiss Nanoscience Institute, Sabancı Üniversitesi

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,030

Funders: European Molecular Biology Organization, Universität Basel, Swiss Nanoscience Institute