Work

Direct synthesis of amides from nitroarenes and carboxylic acids via CO-mediated reduction

Year: 2025

Type: article

Abstract: A highly efficient direct carbon monoxide-mediated protocol for converting nitroarenes and carboxylic acids to amides was developed. Investigation of the reaction kinetics and a Hammett study allowed us to reveal the reaction mechanism and the best reaction conditions. An observed apparent partial reaction order by nitroarene in this reaction is 0.5 indicating the switch of the rate-determining step during the course of the reaction. A highly valuable Vorinostat precursor with 99% purity was synthesized in a quantitative yield without any purification; the E-factor of the process was 0.35, which fits to the multiton chemistry reactions. All substrate scope was prepared using the simple Ru 3 (CO) 12 as a catalyst, and TON up to 44,400 was achieved.

Source: Journal of Catalysis

DOI: 10.1016/j.jcat.2025.116042

Authors: Mikhail A. Losev, Oleg I. Afanasyev, Denis Chusov

Institutions: National Research University Higher School of Economics, A. N. Nesmeyanov Institute of Organoelement Compounds

Language: English

Topic: Asymmetric Hydrogenation and Catalysis

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,250

Funders: Ministry of Education and Science of the Russian Federation, Russian Science Foundation