Hepatitis E-Induced Worsening of Antiphospholipid Syndrome With Extensive Thrombosis: A Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Antiphospholipid syndrome (APS) is an autoimmune disease that can result in a wide range of thromboembolic events. We report on a young male who presented with abdominal pain and was found to have extensive splanchnic vein thrombosis (SVT). Incidentally, he tested positive for the following: hepatitis E virus (HEV) immunoglobulin M (IgM) antibody and antiphospholipid antibodies (aPL), including anticardiolipin and anti-beta2-glycoprotein antibodies. HEV-induced worsening of APS is not a commonly documented occurrence. Cases of APS related to infection may be more prevalent than we suspect and infectious workups in patients with a history of thrombotic events could help discover possible etiologies of acute exacerbations.
Source: Cureus
DOI: 10.7759/cureus.79462
Authors: Abraham Karimi, Sonal Prasad, Edsel Embry, Jay Xiong, Mrinmayee Naik
Institutions: Touro University California, St. Joseph Medical Center
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407858191