Uncommon Oral Manifestations and Growth Failure in A Pediatric Multisystem Langerhans Cell Histiocytosis: A Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Langerhans cell histiocytosis (LCH) is a rare condition characterized by the clonal proliferation of Langerhans cells, leading to varying degrees of organ dysfunction. This report presents a challenging case of multisystem LCH in a 1-year-8-month-old female, exhibiting symptoms like gingival hypertrophy, cutaneous lesions, and failure to thrive. Diagnosis was confirmed by histopathology and immunohistochemistry, which revealed CD1a-positive Langerhans cells. The patient underwent chemotherapy, achieving significant clinical improvement. This report emphasizes the need for vigilance when evaluating pediatric patients with nonspecific symptoms and the importance of a multidisciplinary approach in diagnosing and managing this rare disorder.
Source: Journal of Neonatal Surgery
Authors: Kavya Janardhan, Azmathulla Khan, Mithila Das Mazumder, Manjushree Pushpa, SL Akhila Swaraj, Santoshkumar S Asangi
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407858234