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Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome

Year: 2025

Type: article

Abstract: Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by hyperandrogenism, insulin resistance, and dyslipidemia. Inflammation and oxidative stress play critical roles in its pathogenesis. This observational cross-sectional study evaluated the relationship between serum Caspase-1, interleukin-10 (IL-10), homeostatic model assessment of insulin resistance (HOMA-IR), free androgen index (FAI), lipid profiles, and oxidative stress markers in women with PCOS. Materials and Methods: A total of 150 women diagnosed with PCOS participated in this study. Serum levels of Caspase-1, IL-10, HOMA-IR, FAI, lipid profiles (total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides), malondialdehyde (MDA), and superoxide dismutase (SOD) were measured. Results: The results revealed significant elevations in Caspase-1, HOMA-IR, and lipid profiles, while IL-10 levels were lower compared to normal populations. Additionally, oxidative stress markers, including MDA, were significantly increased, while SOD levels showed a decline. Positive correlations were observed between Caspase-1, HOMA-IR, dyslipidemia, and oxidative stress markers. Conclusion: These findings suggest a crucial link between inflammation, insulin resistance, and oxidative stress in PCOS, contributing to its complex pathophysiology.

Source: Journal of Pharmacy And Bioallied Sciences

DOI: 10.4103/jpbs.jpbs_1994_24

Authors: Neelam Gusain, Ashish Anjankar, Ranjit Ambad

Institution: Datta Meghe Institute of Higher Education and Research

Language: English

Topic: Ovarian function and disorders

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250