Work

Coexisting Primary Biliary Cholangitis and Diffuse Large B-Cell Lymphoma: A Case Report and Literature Review

Year: 2025

Type: article

Abstract: It is recognized that autoimmune diseases such as primary Sjogren's syndrome and rheumatoid arthritis have an increased risk of developing lymphoma, particularly non-Hodgkin's lymphoma (NHL). The progression of primary biliary cholangitis (PBC), a chronic autoimmune liver disease, to lymphoma on this basis has rarely been reported. This article describes a 67-year-old female patient who developed diffuse large B-cell lymphoma (DLBCL) one year after the diagnosis of PBC. She had experienced a transient improvement after receiving treatment but died as a result of infections and other related problems triggered by further immune suppression after chemotherapy. We also reviewed the relevant literature to assess the correlation between PBC and lymphoma risk.

Source: Cureus

DOI: 10.7759/cureus.79508

Authors: Cheng Ma, Xiaoqian Zhang, Hui Yang

Institutions: Changzhi Medical College, Shanxi Medical University, First Hospital of Shanxi Medical University

Language: English

Topic: Liver Diseases and Immunity

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407868537

FWCI:

Cites: 18

Cited by:

Related to: 10