Work

Splicing factor RBM10 loss fuels thyroid cancer metastasis

Year: 2025

Type: article

Abstract: In this issue of JEM, Krishnamoorthy et al. (https://doi.org/10.1084/jem.20241029) identify the loss of the splicing factor RBM10 as a driver of metastasis in thyroid cancer through the regulation of RNA splicing. The synthetic lethal interaction between NF-κB and RBM10 loss reveals a potential therapeutic vulnerability.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20250050

Authors: Kevin Coughlin, Ledong Wan

Institution: Stony Brook University

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Cancer Society, Stony Brook University