Chandipura Virus Cause of a Devastating Outbreak in India's Rural Areas
Year: 2024
Type: article
Abstract: A member of the Rhabdoviridae family, the Chandipura Virus (CHPV), is the cause of a devastating outbreak in India's rural areas. It primarily affects youngsters and is characterized by neurological dysfunctions and a sickness that resembles the flu. Sand flies, ticks, and mosquitoes are among the vectors that spread it. The virus is diagnosed using a reliable real-time, one-step reverse transcriptase PCR test technique. The genome of CHPV has a negative sense RNA that codes for five distinct proteins (N, P, M, G, and L). M protein is naturally deadly, whereas P protein is essential to the virus's life cycle. Mannitol is used as a symptomatic medication to lessen cerebral edema; there is currently no particular treatment for this condition. An effective preventative measure against CHPV was assessed using a vaccine candidate based on Vero cells. The most effective way to reduce CHPV infection is through prevention. To mitigate the spread of CHPV, it will be beneficial to contain disease-transmitting vectors and maintain appropriate diet, health, cleanliness, and knowledge in rural regions. Therefore, until a reliable anti-CHPV agent is created, a number of extreme preventative measures must be tried in order to stop the spread of the virus.
Authors: Vedant V. Patil, Azam Z. Shaikh, S.P. Pawar
Language: English
Topic: Viral Infections and Vectors
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4407878443