Work

Curcumin Electroanalysis at a Disposable Graphite Electrode

Year: 2025

Type: article

Abstract: Curcumin (CU, turmeric), a polyphenolic phytochemical that is largely used as a food spice, has benefits for human health, which have led to increased interest in its therapeutic applications and its analysis from different matrices. The two guaiacol moieties of CU are responsible for its antioxidant properties and allow for its voltammetric quantification. Cyclic and differential pulse voltammetry (DPV) investigations at a single-use pencil graphite electrode (PGE) emphasized complex pH-dependent electrode processes, involving an equal number of protons and electrons. Theoretical calculations predicted a folded geometry for the β-diketone CU conformers, which interact with the PGE surface, exposing the electroactive moieties of only one aromatic ring. The Gibbs energy variations of the structures involved in CU electro-oxidation and the theoretical electrochemical potential values were calculated. CU’s DPV cathodic peak intensity recorded at an HB-type PGE in 0.05 mol × L−1 H2SO4 varied linearly in the range 5.00 × 10−8–5.00 × 10−6 mol × L−1 CU. The method’s detection and quantification limits were 2.12 × 10−8 mol × L−1 and 6.42 × 10−8 mol × L−1, respectively. The practical applicability of the developed method, successfully tested by CU assessment in dietary supplements, provided a recovery of 99.28 ± 2.04%.

Source: Biosensors

DOI: 10.3390/bios15030137

Authors: Mihaela-Carmen Cheregi, Alina Tirsoaga, Cosmina Ion, Emilia-Elena Iorgulescu, Iulia Gabriela David, Hassan Noor

Institutions: University of Bucharest, Lucian Blaga University of Sibiu

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,654

Funder: Universitatea din București