Maternal and Fetal Implications of Oropouche Fever, Espírito Santo State, Brazil, 2024
Year: 2025
Type: article
Study design: Observational Study
Abstract: Reemergence of Oropouche fever in Brazil raises concerns about potential risks for infection in pregnancy. We describe a case series of Oropouche fever in pregnant women and their neonates in Espírito Santo State, Brazil, in 2024. Of 73 pregnancies, 15 pregnancies concluded by the end of the study period; of those, 14 resulted in live births and 1 in spontaneous abortion. Placental reverse transcription PCR tests were positive for Oropouche virus RNA in 5 infections in the third trimester. Two infections occurred in the first trimester, resulting in 1 spontaneous abortion and 1 live birth with corpus callosum dysgenesis. Of 13 infections that occurred in the third trimester, 1 showed possible intrapartum transmission with clinical manifestations in the neonate, whereas the others were asymptomatic. We found no anomalies in third-trimester infections. These findings suggest possible vertical transmission of Oropouche virus and a potential link with spontaneous abortion or malformation.
Source: Emerging infectious diseases
Authors: João Paulo Cola, Ana Paula Brioschi dos Santos, Raphael Lubiana Zanotti, Adriana Endlich da Silva Dela Costa, Karina Bertazo Del Carro, Lesliane de Amorim Lacerda Coelho, Angelica Espinosa Miranda, Creuza Rachel Vicente
Language: English
Topic: Viral Infections and Vectors
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407901924