[Diagnostic Value of Phosphorylated tau217 and Other Plasma Biomarkers for Cognitive Dysfunction in the Populations of Deyang City, Sichuan Province, China].
Year: 2024
Type: other
Abstract: Objective: Alzheimer disease (AD), a continuous disease spectrum, includes the symptomatic stages of the period of mild cognitive impairment (MCI) and the dementia period, also known as AD dementia. Focusing on MCI and AD dementia screening, i.e., AD spectrum screening, we analyzed the value of plasma biomarkers for diagnosing cognitive dysfunction in the local populations of Deyang City, Sichuan Province, China to provide evidence for the early screening and diagnosis of cognitive dysfunction. Methods: A questionnaire survey was conducted between August 2023 and October 2023 among people aged 50 years or older in Deyang City, Sichuan Province. The survey covered demographic information, information on medical history, and cognitive function assessment. Subjects with MCI were included in the MCI group, those with AD dementia were included in the AD group, and the others were included in the healthy controls (HC) group. A partial sample, including all patients with AD dementia and a randomized sample of MCI patients and HC, was drawn. Then, the plasma levels of four cognition-related biomarkers, including phosphorylated tau217 (p-tau217), were measured using an ultrasensitive digital chip immunoassay technology independently developed in China. Amyloid beta (Aβ) deposition was determined by positron emission tomography (PET) using Aβ molecular probes in all AD dementia patients and some of the MCI patients. The diagnostic value of the plasma biomarkers for cognitive dysfunction was assessed. Results: <0.0001). Conclusion: Plasma biomarkers measured with a technology independently developed in China demonstrate good performance in diagnosing AD dementia. Plasma p-tau217, in particular, demonstrates the highest diagnostic value and can be used for AD dementia screening of large populations.
Source: PubMed
DOI: 10.12182/20241160206
Authors: Wanlin Lai, Yilin Xia, Yutong Fu, Zijie Huang, Chao Yang, Yue Wang, Debo Li, Lei Chen
Institutions: Sichuan University, West China Hospital of Sichuan University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4407908022