[Explorative Exmination of Coronary Microcirculatory Ischemia in Type 2 Diabetes Mellitus Patients With One-Stop Cardiac Computed Tomography].
Year: 2024
Type: other
Abstract: Objective: To analyze the differences in computed tomography (CT) myocardial perfusion parameters between type 2 diabetes mellitus (T2DM) patients and nondiabetic patients diagnosed with non-obstructive coronary artery disease (CAD), using a one-stop cardiac CT scanning protocol that combines coronary CT angiography (CCTA) with dynamic CT myocardial perfusion imaging (CT-MPI). In addition, we investigated the effect of T2DM on coronary microcirculatory ischemia. Methods: After balancing the baseline levels with propensity score matching, 92 T2DM patients (the T2DM group) and 92 nondiabetic patients (the nondiabetic group) with non-obstructive CAD were enrolled eventually. The clinical characteristics and the CCTA and CT-MPI results of the two groups were compared. A directed acyclic graph was used to analyze the causal relationships between the variables and to identify key confounding factors. A multivariable regression model was established to evaluate the independent effect of T2DM on the occurrence of coronary microcirculatory ischemia after adjusting for confounding factors. Results: =0.01). Multivariable logistic regression analysis showed that T2DM was an important independent risk factor for coronary microcirculatory ischemia (odds ratio=5.095, 95% confidence interval: 1.753-14.805). Conclusion: According to our assessment with a one-stop cardiac CT scanning protocol combining CCTA and dynamic CT-MPI, patients with non-obstructive CAD and T2DM have reduced global MBF, which makes them more prone to coronary microcirculatory ischemia. Furthermore, T2DM is independently associated with coronary microcirculatory ischemia.
Source: PubMed
DOI: 10.12182/20241160105
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4407908105