[Therapeutic Effect of Cang-Ai Volatile Oil on High-Altitude Rats With Cardiac Hypertrophy Through Modulation of Oxidative Stress Response].
Year: 2024
Type: other
Abstract: Objective: To explore the therapeutic effect of Cang-ai volatile oil (CAVO) on rats with myocardial hypertrophy (MH) exposed to the hypobaric hypoxic environment of the Qinghai-Tibet Plateau using 7.0-tesla (7.0T) cardiac magnetic resonance imaging (CMR). Methods: A total of 50 male specific pathogen-free (SPF) Sprague-Dawley (SD) rats were randomly assigned to a low-altitude control (CON) group, hypobaric hypoxia (HH) group, myocardial hypertrophy modeling (MH) group, MH modeling plus CAVO treatment (MH+CAVO) group, and MH modeling plus benadryl hydrochloride treatment (MH+RX) group, with 10 rats in each group. Except for the CON group, the rats in all the groups were kept and fed in the standard way for 8 weeks in a high-altitude environment (at 4250 m above sea level), and then given the corresponding treatment drugs by gastric gavage. Afterwards, 7.0T high field strength CMR was used to measure left ventricular (LV) function and myocardial strain. Hematoxylin-eosin (HE) staining and Masson staining were performed to observe myocardial interstitial fibrosis. Wheat germ agglutinin (WGA) staining was performed to analyze the cross-sectional area of cardiomyocytes. Transmission electron microscopy was used to observe the ultrastructural changes of the myocardium. Serum levels of cardiac troponin T (cTnT), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-PX) were measured by ELISA. Results: <0.05). Conclusion: CAVO can effectively improve cardiac function in rats with cardiac hypertrophy exposed to high-altitude environment by modulating oxidative stress and ameliorating cardiac hypertrophy.
Source: PubMed
DOI: 10.12182/20241160103
Authors: Boshen Liang, Hongke Yin, Lei Wang, Haotian Chen, Xin Fang, Sisi Zhao, Qi Zhu, Lei Xiong, Jinghang Suo, Baijun Chen, Fabao Gao
Language: English
Topic: High Altitude and Hypoxia
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4407908285