Study on the Mechanism of Positive Regulation of YAP by CD166 in Promoting Occurrence and Development of Liver Cancer
Year: 2025
Type: article
Abstract: This study aims to investigate the role and molecular mechanism of the cell surface molecule CD166 in the occurrence and development of liver cancer. As a malignant tumor with high incidence and mortality, early diagnosis and treatment of liver cancer are of great significance. CD166, known as ALCAM, belongs to the immunoglobulin superfamily, which is intertwined with the ability of tumor cells to proliferate, migrate, and invade. In this study, the expression difference of CD166 in HCC tissues and adjacent normal tissues was analyzed by immunohistochemistry and Western Blot technology. It was found that the expression of CD166 in HCC tissues was significantly upregulated. In further experiments, CD166 in HCC cells was knocked down by RNA interference technology. It was also observed that cell proliferation was inhibited and apoptosis increased, which indicates that CD166 plays a vital role in regulating the growth and survival of HCC cells. The results provide a scientific basis for CD166 as a potential molecular target for early diagnosis and treatment of liver cancer, which is beneficial to promoting liver cancer treatment.
DOI: 10.54097/jwwagq26
Author: Qinghe Ma
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4407947644