Work

Novel One-Step Total Synthesis of trans-Dehydroosthol and Citrubuntin

Year: 2025

Type: article

Abstract: -dehydroosthol and citrubuntin were achieved in a single step by implementing a protecting-group-free, redox-neutral strategy that utilized readily available starting materials. In this approach, a practical one-pot (domino) Heck/dehydration reaction was carried out utilizing less reactive bromocoumarin, resulting in excellent stereoselectivity and atomic economy. Through the implementation of this new, efficient, and scalable synthesis method, the formal synthesis of a series of novel meroterpenoid natural products was successfully achieved.

Source: Molecules

DOI: 10.3390/molecules30051067

Authors: Zhiwen Liu, Baoyue Ge, Xushun Gong, Fusheng Wang, Ting Lei, Shizhi Jiang

Institution: Dali University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funder: National Natural Science Foundation of China