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Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) in a 50-Year-Old Woman

Year: 2025

Type: article

Abstract: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rarepulmonary disorder characterized by hyperplasia of pulmonary neuroendocrine cells.It is frequently asymptomatic and can be challenging to differentiate from other formsof reactive pulmonary neuroendocrine cell hyperplasia (NECH). Presented is a casereport of DIPNECH along with a review of the diagnosis and management. A 50-year-oldfemale patient with a history of airway disease presented to the pulmonary ward withcomplaints of Functional Class III dyspnea and productive cough. The HRCT revealedthe presence of multiple bilateral nodules in both lungs. The histopathology reportfrom the nodule resection confirmed the presence of a carcinoid tumor, specificallyidentified as DIPNECH. As many similar cases have favorable treatment responses andsatisfactory prognoses due to multidisciplinary treatment methods, the necessity ofevidence-based management guidelines for DIPNECH and the accuracy of the diseasedefinition is emphasized.

Source: Case Reports in Clinical Practice

DOI: 10.18502/crcp.v9i4.17980

Authors: Reza Mohseni Ahangar, Faezeh Firuzpour, Cena Aram

Institutions: Babol University of Medical Sciences, Kharazmi University

Language: English

Topic: Neuroendocrine Tumor Research Advances

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407979318

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