Work

Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response

Year: 2025

Type: article

Abstract: • Granulosa Cell Tumor (GCT) represent 2%-5% of ovarian cancers. • Stereotactic Body Radiation Therapy (SBRT) is considered an effective treatment of oligometastatic gynecologic cancer. • SBRT for GCT metastasis demonstrates a marked Inhibin B and radiographic response. • SBRT may be an effective option for local control of GCT recurrence in patients non-amendable to surgical resection. Stereotactic body radiation therapy (SBRT) is a safe and effective treatment for oligometastatic gynecologic cancers. This report details the case of a 75-year-old woman with recurrent granulosa cell tumor of the left ovary. The patient was diagnosed with a peritoneal recurrence after her inhibin-B level increased to 39.7 pg/mL, and a subsequent computed tomography (CT) scan of the abdomen and pelvis revealed an enlarging left-sided soft tissue mass in the sigmoid mesentery measuring 1.2 × 1.2 cm. She underwent SBRT, delivering 37.5 Gy in 5 fractions to the soft tissue mass. A CT scan post-treatment indicated the mass had decreased to 0.8 cm and that her inhibin B level decreased to < 7 pg/mL. This case highlights the effectiveness of SBRT in the management of oligometastatic ovarian cancer, achieving a marked radiographic and tumor marker response in patients with disease not amenable to surgical resection.

Source: Gynecologic Oncology Reports

DOI: 10.1016/j.gore.2025.101708

Authors: Madeline Petty, Vasanti Jhaveri, Nicholas Taylor, Benjamin Foster

Institutions: Temple University, St. Luke's University Health Network, St. Luke's Hospital

Language: English

Topic: Ovarian cancer diagnosis and treatment

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $930