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Extranodal Soft Tissue Rosai-dorfman Disease, a Challenging Diagnosis

Year: 2025

Type: article

Abstract: Rosai-Dorfman disease (RDD) is a rare, benign histiocytic disease of unknown etiology. The characteristic presentation is lymphadenopathy due to abnormal production and accumulation of histiocytes in the lymph nodes. (1) Extranodal presentation may occur in rare instances in the soft tissue, posing a diagnostic dilemma to clinicians and radiologists alike.(2,3) Here, we report a case of a 56 year old lady of Indian descent, who presented with swelling on the left thigh which was clinically diagnosed as a soft tissue neoplasm. Histopathological examination revealed the classical features of RDD. There were large macrophages showing emperipolesis which were surrounded by dense lymphoplasmacytic inltrate. On immunohistochemistry, the histiocytes were positive for S100 and CD68. (4)The diagnosis of extranodal soft tissue RDD was thus conrmed.

Source: GLOBAL JOURNAL FOR RESEARCH ANALYSIS

DOI: 10.36106/gjra/7601039

Authors: Aswathy Gopalakrishnan, Purushotham Basappa, Arsha Narayanan, Jiya Jaleel

Institution: Kannur Medical College

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407983132

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