Work

B suppressor cells and protective autoantibodies

Year: 2025

Type: article

Abstract: Recently the importance of B cells has been highlighted for therapy of several autoimmune diseases including rheumatoid arthritis (RA). Still, the functional role of B cells and antibodies in the disease process are unclear. Using animal models, antibodies specifically binding cartilage are pathogenic, but it has also recently been shown that both B cells and antibodies could be protective. These have specificities that are similar to B cells and autoantibodies detected in humans, including antibodies to citrullinated proteins and collagen type II, and may play an important role hindering an inflammatory attack, whereafter pathogenic B cells and antibodies are functionally more important to initiate and drive the clinically observable disease.

Source: Seminars in Arthritis and Rheumatism

DOI: 10.1016/j.semarthrit.2025.152687

Author: Rikard Holmdahl

Institutions: Karolinska Institutet, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,370