Work

Standardized Fingerroot ( Boesenbergia pandurata ) Extract Decelerates the Development of Sarcopenia in Aged Rats

Year: 2025

Type: article

Abstract: extract, BPE) standardized with panduratin A on sarcopenia in aged rats. The results showed that BPE significantly increased the weights of the gastrocnemius and tibialis anterior muscle tissues and the cross-sectional area of the muscle fibers. In addition, BPE activated the phosphoinositide 3-kinase/Akt pathway, thereby activating the mammalian target of rapamycin pathway for protein formation and inhibiting proteolysis by decreasing forkhead box O3a-mediated muscle-specific ubiquitin ligases. BPE not only reduced tumor necrosis factor alpha and interleukin-6 levels but also stimulated the activities and mRNA expression of catalase and superoxide dismutase. The results suggest that BPE can be used as a functional food ingredient to inhibit or decelerate sarcopenia progression.

Source: Preventive Nutrition and Food Science

DOI: 10.3746/pnf.2025.30.1.47

Authors: Changhee Kim, Minseong Kang, Yeeun Kim, Jae-Kwan Hwang

Institution: Yonsei University

Language: English

Topic: Nutrition and Health in Aging

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: hybrid

Funder: Ministry of Trade, Industry and Energy