Comprehensive analysis of relapsed‐refractory mature B‐cell non‐Hodgkin lymphoma in children and adolescents
Year: 2025
Type: article
Study design: Observational Study
Abstract: The outcome of B-cell non-Hodgkin lymphoma (B-NHL) in children and adolescents has improved significantly over recent decades due to risk-adapted strategies and the use of immunotherapy. However, refractory or relapsed (R/R) B-NHL remains extremely difficult to cure (<30%). This retrospective study of 45 patients with R/R B-NHL reflects the limited benefit associated with reintroducing rituximab in second-line strategies, the importance of achieving complete remission before stem cell transplantation and the potential role of TP53 as a biomarker in R/R B-NHL. TP53 mutations were identified in 44% of tumours and associated with a worse 3-year overall survival (15% vs. 80%; p = 0.048).
Source: British Journal of Haematology
DOI: 10.1111/bjh.20012
Authors: Sara Mato, Lorenzo Carità, Ariadna Colmenero, Mara Andrés, Olga Balagué, Maitane Andión, Itziar Astigarraga, Verónica Celis, Carmen Mendoza, Pilar Guerra‐García, Lorena Valero, Ana Galera, María Tallón, Melina Pol, Natalia Castrejón‐de‐Anta, Leonie Frauenfeld, Noelia Garcia, Elías Campo, Itziar Salaverria, Jaime Verdú‐Amorós
Institutions: Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Hospital Universitari i Politècnic La Fe, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Cáncer, Hospital Infantil Universitario Niño Jesús, University of the Basque Country, Hospital de Cruces, Hospital Sant Joan de Déu Barcelona, Complejo Hospitalario de Salamanca, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Vall d'Hebron Hospital Universitari, Hospital Universitario Virgen de la Arrixaca, INCLIVA Health Research Institute
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Awards: G1333893837, G1795813253, G235115530, G2420584257, Mecanismos genéticos en el desarrollo del linfoma no-Hodgkin pediátrico en pacientes inmunocompetentes y con inmunodeficiencia primaria, G3480400115, G3525093752, Mutaciones con impacto diagnóstico y pronóstico en linfoma No-Hodgkin en pacientes inmunocompetentes y posttrasplante (PTLD) pediátricos y adultos jóvenes, G4475295514, G5450132471
OpenAlex ID: W4408026479