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Prophylactic Administration of Low Dose Midazolam and Ketamine in Prevention of Profound Hypotension in Severely Anxious Females Undergoing Cesarean Section

Year: 2025
Type: article
Study design: Clinical Trial
Abstract: Objective: To compare the efficacy of a combination of Midazolam and Ketamine in providing anxiolysis to prevent profound hypotension in severely anxious patients undergoing cesarean section. Study Design: Quasi-Experimental Study Place and Duration of Study: Combined Military Hospital Quetta, Pakistan from Mar to Apr 2023. Methodology: The study population included female patients of reproductive age group undergoing lower segment cesarean section under spinal anesthesia. A total of 100 patients were recruited. The study sample was divided into two sets. The first set of patients was labeled Group-A and second was labeled as Group-B. Visual Analogue Scale for Anxiety (VAS‐A) was used to assess the anxiety in all patients. Group-A received premedication (Ketamine and Midazolam) and Group-B patients didn’t receive the premedication and they were only given Verbal Reassurance. The primary outcome was frequency of hypotension in patients of moderate-severe anxiety. Results: The frequency of the adverse outcomes was higher in Group-B as compared to Group-A. The frequency of tachycardia was 1(2%) versus 17(34%), hypotension was 1(2%) versus 17(34%), nausea/vomiting was 2(4%) versus 9(18%), shivering was 2(4%) versus 9(18%), and Diaphoresis was 2(4%) versus 5(10%) in Group-A versus Group-B respectively. Conclusion: The combination of low dose Midazolam (0.03mg/kg) and Ketamine (0.2mg/kg) prevents anxiety related hypotension in gravid female undergoing cesarean section under spinal anesthesia.
DOI: 10.51253/pafmj.v75i1.10888
Authors: Kaukab Majeed, Chaudhry Amjad Ali, Fatima Sharif Khan, Akhtar Hussain, Kaswar Sajjad Ansari, Sajjad Qureshi
Language: English
Field: Medicine
Open Access status: diamond
OpenAlex ID: W4408028554
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