New solutions for antibiotic discovery: Prioritizing microbial biosynthetic space using ecology and machine learning
Year: 2025
Type: article
Abstract: With the explosive increase in genome sequence data, perhaps the major challenge in natural-product-based drug discovery is the identification of gene clusters most likely to specify new chemistry and bioactivities. We discuss the challenges and state-of-the-art of antibiotic discovery based on ecological principles, genome mining and artificial intelligence.
Source: PLoS Biology
Authors: Marnix H. Medema, Gilles P. van Wezel
Institutions: Leiden University, Wageningen University & Research
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,500
OpenAlex ID: W4408029840