Work

Spectroscopic Study of Methylene Blue Interaction with Coenzymes and Its Effect on Tumor Metabolism

Year: 2025

Type: article

Abstract: . Materials and Methods: was assessed using time-resolved fluorescence microscopy based on the NADH fluorescence lifetime. Results: , no noticeable tumor growth rate reduction was observed in the groups with intravenous MB introduction in comparison with the control. In the group receiving MB with drinking water, a decrease of the tumor growth rate, reduction of oxygenation level, and a1/a2 metabolic index were observed, which confirms the shift from glycolysis to oxidative phosphorylation. Conclusion: The possibility of using MB for the tumor metabolism correction and growth rate reduction has been demonstrated, however, the time of therapy and MB concentration should be optimized to obtain more pronounced therapeutic effect.

Source: Современные технологии в медицине

DOI: 10.17691/stm2025.17.1.02

Authors: D.V. Pominova, A.V. Ryabova, A.S. Skobeltsin, I.V. Markova, I.D. Romanishkin

Institutions: Russian Academy of Sciences, Prokhorov General Physics Institute, National Research Nuclear University MEPhI

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Russian Science Foundation